Reactome | Sequestration of BAD protein by 14-3-3

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Sequestration of BAD protein by 14-3-3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
dbId	139899
displayName	Sequestration of BAD protein by 14-3-3
eventOf	[Pathway:R-HSA-111447] Activation of BAD and translocation to mitochondria - Homo sapiens
followingEvent	[Reaction:R-HSA-139906] Activation of BAD by calcineurin - Homo sapiens
input	[DefinedSet:R-HSA-1445138] 14-3-3 dimer [cytosol] [EntityWithAccessionedSequence:R-HSA-198335] p-S99-BAD [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3139020] 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation [LiteratureReference:140433] Cleavage of 14-3-3 protein by caspase-3 facilitates bad interaction with Bcl-x(L) during apoptosis [LiteratureReference:3143411] Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis [LiteratureReference:3143412] Association of 14-3-3gamma and phosphorylated bad attenuates injury in ischemic astrocytes
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Sequestration of BAD protein by 14-3-3
orthologousEvent	[Reaction:R-XTR-139899] Sequestration of BAD protein by 14-3-3 - Xenopus tropicalis [Reaction:R-DRE-139899] Sequestration of BAD protein by 14-3-3 - Danio rerio [Reaction:R-SSC-139899] Sequestration of BAD protein by 14-3-3 - Sus scrofa [Reaction:R-BTA-139899] Sequestration of BAD protein by 14-3-3 - Bos taurus [Reaction:R-CFA-139899] Sequestration of BAD protein by 14-3-3 - Canis familiaris [Reaction:R-RNO-139899] Sequestration of BAD protein by 14-3-3 - Rattus norvegicus [Reaction:R-MMU-139899] Sequestration of BAD protein by 14-3-3 - Mus musculus
output	[Complex:R-HSA-139904] 14-3-3 proteins:p-S99-BAD complex [cytosol]
precedingEvent	[Reaction:R-HSA-198347] AKT phosphorylates BAD - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:3139052] Orlic-Milacic, M, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-139899
summation	[Summation:179175] 14-3-3 proteins bind BAD phosphorylated by activated AKT on ...
updateTrackers	[UpdateTracker:9787909] Update Tracker - [Reaction:139899] Sequestration of BAD protein by 14-3-3 - v44:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787909] Update Tracker - [Reaction:139899] Sequestration of BAD protein by 14-3-3 - v44:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-111447] Activation of BAD and translocation to mitochondria
(precedingEvent)	[Reaction:R-HSA-139906] Activation of BAD by calcineurin