Activation of BAD and translocation to mitochondria

Stable Identifier
R-HSA-111447
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of BAD and translocation to mitochondria
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The switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activates BAD by dephosphorylation.
Literature References
PubMed ID Title Journal Year
15231831 BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function.

Seo, SY, Chen, YB, Ivanovska, I, Ranger, AM, Hong, SJ, Dawson, VL, Korsmeyer, SJ, Bellows, DS, Fannjiang, Y, Hardwick, JM

J Biol Chem 2004
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as an event of
Event Information
Go Biological Process
positive regulation of establishment of protein localization to mitochondrion (1903749)
Orthologous Events
Activation of BAD and translocation to mitochondria (Bos taurus)
Activation of BAD and translocation to mitochondria (Canis familiaris)
Activation of BAD and translocation to mitochondria (Danio rerio)
Activation of BAD and translocation to mitochondria (Mus musculus)
Activation of BAD and translocation to mitochondria (Rattus norvegicus)
Activation of BAD and translocation to mitochondria (Sus scrofa)
Activation of BAD and translocation to mitochondria (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Gopinathrao, G  (2004-08-20)
Reviewed
Vaux, DL  (2025-11-12)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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