Reactome | APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site

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APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5649547] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
dbId	110359
displayName	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-73933] Resolution of Abasic Sites (AP sites) - Homo sapiens
followingEvent	[Reaction:R-HSA-110360] Recruitment of POLB to the AP site - Homo sapiens [BlackBoxEvent:R-HSA-5649856] Oxidative damage to the AP site - Homo sapiens
input	[Complex:R-HSA-110332] APEX1:AP-dsDNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5637648] Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA [LiteratureReference:111255] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. [LiteratureReference:111250] Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product. [LiteratureReference:111242] Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
orthologousEvent	[Reaction:R-PFA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Plasmodium falciparum [Reaction:R-DDI-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Dictyostelium discoideum [Reaction:R-CEL-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Caenorhabditis elegans [Reaction:R-DME-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Drosophila melanogaster [Reaction:R-XTR-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Xenopus tropicalis [Reaction:R-DRE-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Danio rerio [Reaction:R-SSC-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Sus scrofa [Reaction:R-BTA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Bos taurus [Reaction:R-CFA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Canis familiaris [Reaction:R-RNO-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Rattus norvegicus [Reaction:R-MMU-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Mus musculus
output	[Complex:R-HSA-110334] APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110350] Displacement of TDG glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-110359
summation	[Summation:178472] APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site DN...
updateTrackers	[UpdateTracker:9785356] Update Tracker - [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - v52:[add_removeCatalystActivity, modifyText] [UpdateTracker:9785822] Update Tracker - [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - v51:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785356] Update Tracker - [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - v52:[add_removeCatalystActivity, modifyText] [UpdateTracker:9785822] Update Tracker - [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - v51:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-110360] Recruitment of POLB to the AP site [BlackBoxEvent:R-HSA-5649856] Oxidative damage to the AP site
(hasEvent)	[Pathway:R-HSA-73933] Resolution of Abasic Sites (AP sites)

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