Reactome | Resolution of Abasic Sites (AP sites)

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Resolution of Abasic Sites (AP sites) Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
dbId	73933
displayName	Resolution of Abasic Sites (AP sites)
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-73884] Base Excision Repair - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17139] base-excision repair, gap-filling
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-110357] Displacement of DNA glycosylase by APEX1 - Homo sapiens [Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Homo sapiens [Pathway:R-HSA-110381] Resolution of AP sites via the single-nucleotide replacement pathway - Homo sapiens [Pathway:R-HSA-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Homo sapiens [Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:5637648] Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA [LiteratureReference:111255] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. [LiteratureReference:111250] Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product. [LiteratureReference:111257] Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. [LiteratureReference:111248] Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). [LiteratureReference:5649874] DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis [LiteratureReference:5651823] Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair [LiteratureReference:5651761] Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex [LiteratureReference:176142] The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1 [LiteratureReference:5651927] The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase [LiteratureReference:5651919] The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery [LiteratureReference:5649703] AP endonuclease-independent DNA base excision repair in human cells [LiteratureReference:5649714] NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Resolution of Abasic Sites (AP sites)
orthologousEvent	[Pathway:R-MMU-73933] Resolution of Abasic Sites (AP sites) - Mus musculus [Pathway:R-RNO-73933] Resolution of Abasic Sites (AP sites) - Rattus norvegicus [Pathway:R-CFA-73933] Resolution of Abasic Sites (AP sites) - Canis familiaris [Pathway:R-BTA-73933] Resolution of Abasic Sites (AP sites) - Bos taurus [Pathway:R-SSC-73933] Resolution of Abasic Sites (AP sites) - Sus scrofa [Pathway:R-DRE-73933] Resolution of Abasic Sites (AP sites) - Danio rerio [Pathway:R-XTR-73933] Resolution of Abasic Sites (AP sites) - Xenopus tropicalis [Pathway:R-GGA-73933] Resolution of Abasic Sites (AP sites) - Gallus gallus [Pathway:R-DME-73933] Resolution of Abasic Sites (AP sites) - Drosophila melanogaster [Pathway:R-CEL-73933] Resolution of Abasic Sites (AP sites) - Caenorhabditis elegans [Pathway:R-DDI-73933] Resolution of Abasic Sites (AP sites) - Dictyostelium discoideum [Pathway:R-SPO-73933] Resolution of Abasic Sites (AP sites) - Schizosaccharomyces pombe [Pathway:R-SCE-73933] Resolution of Abasic Sites (AP sites) - Saccharomyces cerevisiae [Pathway:R-PFA-73933] Resolution of Abasic Sites (AP sites) - Plasmodium falciparum
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-73933
summation	[Summation:212977] Resolution of AP sites can occur through the single nucleoti...
updateTrackers	[UpdateTracker:9790556] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v33:[updateContainedPathway] [UpdateTracker:9789714] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v37:[updateContainedPathway] [UpdateTracker:9784876] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v52:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9792020] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v24:[addSummation, updateContainedPathway] [UpdateTracker:9786450] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v49:[updateContainedPathway] [UpdateTracker:9781942] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v60:[updateContainedPathway] [UpdateTracker:9783139] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v57:[updateIndirectRLE] [UpdateTracker:9779434] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v65:[updateIndirectRLE] [UpdateTracker:9785803] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v51:[updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-73884] Base Excision Repair
(hasEncapsulatedEvent)	[Pathway:R-HSA-73929] Base-Excision Repair, AP Site Formation
(updatedInstance)	[UpdateTracker:9790556] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v33:[updateContainedPathway] [UpdateTracker:9789714] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v37:[updateContainedPathway] [UpdateTracker:9784876] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v52:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9792020] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v24:[addSummation, updateContainedPathway] [UpdateTracker:9786450] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v49:[updateContainedPathway] [UpdateTracker:9781942] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v60:[updateContainedPathway] [UpdateTracker:9783139] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v57:[updateIndirectRLE] [UpdateTracker:9779434] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v65:[updateIndirectRLE] [UpdateTracker:9785803] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v51:[updateIndirectRLE]

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