Reactome | Displacement of MPG glycosylase by APEX1 at the AP site

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Displacement of MPG glycosylase by APEX1 at the AP site Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
dbId	110356
displayName	Displacement of MPG glycosylase by APEX1 at the AP site
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110357] Displacement of DNA glycosylase by APEX1 - Homo sapiens
followingEvent	[Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-50119] APEX1 [nucleoplasm] [Complex:R-HSA-110207] MPG:AP-dsDNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5637618] Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Displacement of MPG glycosylase by APEX1 at the AP site
orthologousEvent	[Reaction:R-PFA-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Plasmodium falciparum [Reaction:R-XTR-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-DRE-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Danio rerio [Reaction:R-SSC-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Sus scrofa [Reaction:R-BTA-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Bos taurus [Reaction:R-CFA-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Canis familiaris [Reaction:R-RNO-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Rattus norvegicus [Reaction:R-MMU-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Mus musculus
output	[Complex:R-HSA-110332] APEX1:AP-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-49155] MPG [nucleoplasm]
precedingEvent	[Reaction:R-HSA-110248] Cleavage of 3-methyladenine by MPG glycosylase - Homo sapiens [Reaction:R-HSA-110250] Cleavage of ethenoadenine by MPG glycosylase - Homo sapiens [Reaction:R-HSA-110251] Cleavage of hypoxanthine by MPG glycosylase - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-110356
summation	[Summation:178675] APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site ly...
updateTrackers	[UpdateTracker:9785185] Update Tracker - [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site - v52:[modifyText] [UpdateTracker:9785813] Update Tracker - [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site - v51:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785185] Update Tracker - [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site - v52:[modifyText] [UpdateTracker:9785813] Update Tracker - [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site - v51:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
(hasEvent)	[Pathway:R-HSA-110357] Displacement of DNA glycosylase by APEX1

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