Reactome | APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site

Schema > Reaction > Entries

APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site Show undefined attributes

catalystActivity	[CatalystActivity:10657478] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10657480
displayName	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
eventOf	[Pathway:R-XTR-73933] Resolution of Abasic Sites (AP sites) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-110360] Recruitment of POLB to the AP site - Xenopus tropicalis [BlackBoxEvent:R-XTR-5649856] Oxidative damage to the AP site - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Homo sapiens
input	[Complex:R-XTR-110332] APEX1:AP-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
output	[Complex:R-XTR-110334] APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-XTR-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110350] Displacement of TDG glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-110359
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-73933] Resolution of Abasic Sites (AP sites)
(precedingEvent)	[Reaction:R-XTR-110360] Recruitment of POLB to the AP site [BlackBoxEvent:R-XTR-5649856] Oxidative damage to the AP site
(inferredTo)	[Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site