Reactome | APEX1:AP-dsDNA [nucleoplasm]

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APEX1:AP-dsDNA [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:5649547] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Homo sapiens
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
dbId	110332
displayName	APEX1:AP-dsDNA [nucleoplasm]
hasComponent	[GenomeEncodedEntity:R-HSA-110187] AP-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-50119] APEX1 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-110332] APEX1:AP-dsDNA [nucleoplasm] - Mus musculus [Complex:R-RNO-110332] APEX1:AP-dsDNA [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-110332] APEX1:AP-dsDNA [nucleoplasm] - Canis familiaris [Complex:R-BTA-110332] APEX1:AP-dsDNA [nucleoplasm] - Bos taurus [Complex:R-SSC-110332] APEX1:AP-dsDNA [nucleoplasm] - Sus scrofa [Complex:R-DRE-110332] APEX1:AP-dsDNA [nucleoplasm] - Danio rerio [Complex:R-XTR-110332] APEX1:AP-dsDNA [nucleoplasm] - Xenopus tropicalis [Complex:R-DME-110332] APEX1:AP-dsDNA [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-110332] APEX1:AP-dsDNA [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-110332] APEX1:AP-dsDNA [nucleoplasm] - Dictyostelium discoideum [Complex:R-PFA-110332] APEX1:AP-dsDNA [nucleoplasm] - Plasmodium falciparum
maxDepth	2
modified	[InstanceEdit:5649551] Orlic-Milacic, Marija, 2014-11-20
name	APEX1:AP-dsDNA DNA containing an APE1-bound AP site
producedByEvent	[Reaction:R-HSA-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110350] Displacement of TDG glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-110332
updateTrackers	[UpdateTracker:9891303] Update Tracker - [Complex:110332] APEX1:AP-dsDNA [nucleoplasm] - v52:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9891303] Update Tracker - [Complex:110332] APEX1:AP-dsDNA [nucleoplasm] - v52:[addName]
(input)	[Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
(physicalEntity)	[CatalystActivity:5649547] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
(output)	[Reaction:R-HSA-110350] Displacement of TDG glycosylase by APEX1 at the AP site [Reaction:R-HSA-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site [Reaction:R-HSA-110349] Displacement of UNG glycosylase by APEX1 at the AP site [Reaction:R-HSA-110356] Displacement of MPG glycosylase by APEX1 at the AP site [Reaction:R-HSA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Reaction:R-HSA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site [Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Reaction:R-HSA-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site

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