Reactome | Displacement of DNA glycosylase by APEX1

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Displacement of DNA glycosylase by APEX1 Show undefined attributes

authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
dbId	110357
displayName	Displacement of DNA glycosylase by APEX1
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-73933] Resolution of Abasic Sites (AP sites) - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110350] Displacement of TDG glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Homo sapiens [Reaction:R-HSA-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:111242] Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Displacement of DNA glycosylase by APEX1
orthologousEvent	[Pathway:R-PFA-110357] Displacement of DNA glycosylase by APEX1 - Plasmodium falciparum [Pathway:R-DDI-110357] Displacement of DNA glycosylase by APEX1 - Dictyostelium discoideum [Pathway:R-CEL-110357] Displacement of DNA glycosylase by APEX1 - Caenorhabditis elegans [Pathway:R-DME-110357] Displacement of DNA glycosylase by APEX1 - Drosophila melanogaster [Pathway:R-XTR-110357] Displacement of DNA glycosylase by APEX1 - Xenopus tropicalis [Pathway:R-DRE-110357] Displacement of DNA glycosylase by APEX1 - Danio rerio [Pathway:R-SSC-110357] Displacement of DNA glycosylase by APEX1 - Sus scrofa [Pathway:R-BTA-110357] Displacement of DNA glycosylase by APEX1 - Bos taurus [Pathway:R-CFA-110357] Displacement of DNA glycosylase by APEX1 - Canis familiaris [Pathway:R-RNO-110357] Displacement of DNA glycosylase by APEX1 - Rattus norvegicus [Pathway:R-MMU-110357] Displacement of DNA glycosylase by APEX1 - Mus musculus
precedingEvent	[Pathway:R-HSA-73927] Depurination - Homo sapiens [Pathway:R-HSA-73928] Depyrimidination - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-110357
summation	[Summation:212503] Following cleavage of the damaged base, DNA glycosylase is d...
updateTrackers	[UpdateTracker:9792029] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v24:[addSummation] [UpdateTracker:9785855] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v51:[updateContainedRLE] [UpdateTracker:9785511] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v52:[modifyText, updateContainedRLE] [UpdateTracker:9787916] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v44:[updateContainedRLE] [UpdateTracker:9779388] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v65:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9792029] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v24:[addSummation]
[UpdateTracker:9785855] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v51:[updateContainedRLE]
[UpdateTracker:9785511] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v52:[modifyText, updateContainedRLE]
[UpdateTracker:9787916] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v44:[updateContainedRLE]
[UpdateTracker:9779388] Update Tracker - [Pathway:110357] Displacement of DNA glycosylase by APEX1 - v65:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-73933] Resolution of Abasic Sites (AP sites)

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