Reactome | Apoptosis

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Apoptosis Show undefined attributes

authored	[InstanceEdit:109608] Alnemri, E, Hengartner, Michael, Tschopp, J�rg, Tsujimoto, Yoshihide, Hardwick, JM, 2004-01-16
created	[InstanceEdit:109608] Alnemri, E, Hengartner, Michael, Tschopp, J�rg, Tsujimoto, Yoshihide, Hardwick, JM, 2004-01-16
dbId	109581
displayName	Apoptosis
edited	[InstanceEdit:165111] Gopinathrao, G, Matthews, L, Gillespie, ME, Joshi-Tope, G, 0000-00-00 00:00:00
eventOf	[TopLevelPathway:R-HSA-5357801] Programmed Cell Death - Homo sapiens
figure	[Figure:9628944] /figures/ehld/R-HSA-109581.svg
goBiologicalProcess	[GO_BiologicalProcess:2273] apoptotic process
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway - Homo sapiens [Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis - Homo sapiens [Pathway:R-HSA-75153] Apoptotic execution phase - Homo sapiens [Pathway:R-HSA-169911] Regulation of Apoptosis - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:141229] Apoptosis and disease: a life or death decision [LiteratureReference:141235] Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics [LiteratureReference:141241] History of the events leading to the formulation of the apoptosis concept [LiteratureReference:140372] Ways of dying: multiple pathways to apoptosis. [LiteratureReference:140368] The Bcl-2 family: roles in cell survival and oncogenesis. [LiteratureReference:141074] Targeting death and decoy receptors of the tumour-necrosis factor superfamily [LiteratureReference:140546] The Bcl2 family: regulators of the cellular life-or-death switch
maxDepth	7
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Apoptosis
orthologousEvent	[Pathway:R-CFA-109581] Apoptosis - Canis familiaris [Pathway:R-BTA-109581] Apoptosis - Bos taurus [Pathway:R-SSC-109581] Apoptosis - Sus scrofa [Pathway:R-DRE-109581] Apoptosis - Danio rerio [Pathway:R-XTR-109581] Apoptosis - Xenopus tropicalis [Pathway:R-GGA-109581] Apoptosis - Gallus gallus [Pathway:R-DME-109581] Apoptosis - Drosophila melanogaster [Pathway:R-CEL-109581] Apoptosis - Caenorhabditis elegans [Pathway:R-DDI-109581] Apoptosis - Dictyostelium discoideum [Pathway:R-SPO-109581] Apoptosis - Schizosaccharomyces pombe [Pathway:R-SCE-109581] Apoptosis - Saccharomyces cerevisiae [Pathway:R-PFA-109581] Apoptosis - Plasmodium falciparum [Pathway:R-RNO-109581] Apoptosis - Rattus norvegicus [Pathway:R-MMU-109581] Apoptosis - Mus musculus
releaseDate	2004-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165110] Hengartner, M, Ranganathan, S, Vaux, D, 0000-00-00 00:00:00
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-109581
summation	[Summation:109577] Apoptosis is a distinct form of cell death that is functiona...
updateTrackers	[UpdateTracker:9778663] Update Tracker - [Pathway:109581] Apoptosis - v68:[updateContainedPathway] [UpdateTracker:9779816] Update Tracker - [Pathway:109581] Apoptosis - v64:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790829] Update Tracker - [Pathway:109581] Apoptosis - v32:[updateContainedPathway] [UpdateTracker:9785729] Update Tracker - [Pathway:109581] Apoptosis - v51:[add_removeHasEvent, updateContainedPathway] [UpdateTracker:9782983] Update Tracker - [Pathway:109581] Apoptosis - v58:[updateContainedPathway] [UpdateTracker:9790785] Update Tracker - [Pathway:109581] Apoptosis - v33:[removeHasEvent, updateContainedPathway] [UpdateTracker:9792165] Update Tracker - [Pathway:109581] Apoptosis - v23:[removeHasEvent, updateContainedPathway] [UpdateTracker:9791920] Update Tracker - [Pathway:109581] Apoptosis - v25:[addHasEvent, updateContainedPathway] [UpdateTracker:9782435] Update Tracker - [Pathway:109581] Apoptosis - v59:[updateIndirectRLE] [UpdateTracker:9789347] Update Tracker - [Pathway:109581] Apoptosis - v38:[addLiteratureReference, updateContainedPathway] [UpdateTracker:9774761] Update Tracker - [Pathway:109581] Apoptosis - v81:[updateContainedPathway] [UpdateTracker:9780496] Update Tracker - [Pathway:109581] Apoptosis - v63:[updateContainedPathway] [UpdateTracker:9786742] Update Tracker - [Pathway:109581] Apoptosis - v48:[updateContainedPathway] [UpdateTracker:9785199] Update Tracker - [Pathway:109581] Apoptosis - v52:[add_removeHasEvent] [UpdateTracker:9779664] Update Tracker - [Pathway:109581] Apoptosis - v65:[updateContainedPathway] [UpdateTracker:9777652] Update Tracker - [Pathway:109581] Apoptosis - v70:[updateContainedPathway] [UpdateTracker:9791747] Update Tracker - [Pathway:109581] Apoptosis - v26:[updateContainedPathway] [UpdateTracker:9791959] Update Tracker - [Pathway:109581] Apoptosis - v24:[updateContainedPathway] [UpdateTracker:9787781] Update Tracker - [Pathway:109581] Apoptosis - v44:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778782] Update Tracker - [Pathway:109581] Apoptosis - v67:[updateContainedPathway] [UpdateTracker:9786531] Update Tracker - [Pathway:109581] Apoptosis - v49:[updateContainedPathway] [UpdateTracker:9789557] Update Tracker - [Pathway:109581] Apoptosis - v37:[updateContainedPathway]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-5357801] Programmed Cell Death
(hasEncapsulatedEvent)	[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade [Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis [Pathway:R-HSA-166166] MyD88-independent TLR4 cascade
(updatedInstance)	[UpdateTracker:9778663] Update Tracker - [Pathway:109581] Apoptosis - v68:[updateContainedPathway] [UpdateTracker:9779816] Update Tracker - [Pathway:109581] Apoptosis - v64:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790829] Update Tracker - [Pathway:109581] Apoptosis - v32:[updateContainedPathway] [UpdateTracker:9785729] Update Tracker - [Pathway:109581] Apoptosis - v51:[add_removeHasEvent, updateContainedPathway] [UpdateTracker:9782983] Update Tracker - [Pathway:109581] Apoptosis - v58:[updateContainedPathway] [UpdateTracker:9790785] Update Tracker - [Pathway:109581] Apoptosis - v33:[removeHasEvent, updateContainedPathway] [UpdateTracker:9792165] Update Tracker - [Pathway:109581] Apoptosis - v23:[removeHasEvent, updateContainedPathway] [UpdateTracker:9791920] Update Tracker - [Pathway:109581] Apoptosis - v25:[addHasEvent, updateContainedPathway] [UpdateTracker:9782435] Update Tracker - [Pathway:109581] Apoptosis - v59:[updateIndirectRLE] [UpdateTracker:9789347] Update Tracker - [Pathway:109581] Apoptosis - v38:[addLiteratureReference, updateContainedPathway] [UpdateTracker:9774761] Update Tracker - [Pathway:109581] Apoptosis - v81:[updateContainedPathway] [UpdateTracker:9780496] Update Tracker - [Pathway:109581] Apoptosis - v63:[updateContainedPathway] [UpdateTracker:9786742] Update Tracker - [Pathway:109581] Apoptosis - v48:[updateContainedPathway] [UpdateTracker:9785199] Update Tracker - [Pathway:109581] Apoptosis - v52:[add_removeHasEvent] [UpdateTracker:9779664] Update Tracker - [Pathway:109581] Apoptosis - v65:[updateContainedPathway] [UpdateTracker:9777652] Update Tracker - [Pathway:109581] Apoptosis - v70:[updateContainedPathway] [UpdateTracker:9791747] Update Tracker - [Pathway:109581] Apoptosis - v26:[updateContainedPathway] [UpdateTracker:9791959] Update Tracker - [Pathway:109581] Apoptosis - v24:[updateContainedPathway] [UpdateTracker:9787781] Update Tracker - [Pathway:109581] Apoptosis - v44:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778782] Update Tracker - [Pathway:109581] Apoptosis - v67:[updateContainedPathway] [UpdateTracker:9786531] Update Tracker - [Pathway:109581] Apoptosis - v49:[updateContainedPathway] [UpdateTracker:9789557] Update Tracker - [Pathway:109581] Apoptosis - v37:[updateContainedPathway]

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