GAF binds the GAS promoter elements in the IFNG-regulated genes

Stable Identifier
R-HSA-1031713
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GAF binds the GAS promoter elements in the IFNG-regulated genes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GAF transcription factor translocated into nucleus binds to defined DNA sequence called GAS (gamma activated sequence) elements in the promoters of IFN-gamma responsive elements and initiate transcription.
Literature References
PubMed ID Title Journal Year
1898761 Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

Darnell, JE, Strehlow, I, Decker, T, Lew, DJ

Mol Cell Biol 1991
1901265 Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor

Mirkovitch, J, Darnell JE, Jr, Decker, T, Lew, DJ

EMBO J 1991
1281555 Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

Darnell JE, Jr, Prezioso, VR, Schindler, C, Shuai, K

Science 1992
9143706 Cellular responses to interferon-gamma

Groot, M, Howard, JC, Boehm, U, Klamp, T

Annu Rev Immunol 1997
Participants
Input
Output
Participates
as an event of
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-11-18)
Cite Us!