Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate
Show undefined attributes
Go to Details
authored
[InstanceEdit:8866600] D'Eustachio, Peter, 2016-04-01
catalystActivity
[CatalystActivity:8866631] triphosphoric monoester hydrolase activity of SAMHD1:Zn2+ tetramer [nucleoplasm]
catalystActivityReference
[CatalystActivityReference:9644078] triphosphoric monoester hydrolase activity of SAMHD1:Zn2+ tetramer [nucleoplasm] HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:8866600] D'Eustachio, Peter, 2016-04-01
crossReference
[DatabaseIdentifier:12667811] RHEA:46149
[DatabaseIdentifier:9976513] RHEA:46149
dbId
8866601
displayName
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate
edited
[InstanceEdit:8866600] D'Eustachio, Peter, 2016-04-01
eventOf
[Pathway:R-HSA-8956319] Nucleotide catabolism - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:16834] deoxyribonucleotide catabolic process
input
[SimpleEntity:R-ALL-8866574] dNTP(4-) [nucleoplasm]
[SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8866620] The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells
[LiteratureReference:8866632] HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
[LiteratureReference:8866603] Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
[LiteratureReference:8866588] Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response
[LiteratureReference:8866610] Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection
[LiteratureReference:8866571] Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate
a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + triphosphate + H(+)
orthologousEvent
[Reaction:R-PFA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Plasmodium falciparum
[Reaction:R-DDI-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Dictyostelium discoideum
[Reaction:R-CEL-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Caenorhabditis elegans
[Reaction:R-DME-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Drosophila melanogaster
[Reaction:R-GGA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Gallus gallus
[Reaction:R-XTR-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Xenopus tropicalis
[Reaction:R-DRE-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Danio rerio
[Reaction:R-SSC-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Sus scrofa
[Reaction:R-BTA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Bos taurus
[Reaction:R-CFA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Canis familiaris
[Reaction:R-RNO-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Rattus norvegicus
[Reaction:R-MMU-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Mus musculus
output
[SimpleEntity:R-ALL-8866608] 2'-deoxynucleoside [nucleoplasm]
[SimpleEntity:R-ALL-9668967] H+ [nucleoplasm]
[SimpleEntity:R-ALL-8866567] PPPi [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-1015702] Expression of IFN-induced genes - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-8866639] Positive regulation by 'dGTP [nucleoplasm]'
regulationReference
[RegulationReference:9641384] Positive regulation by 'dGTP [nucleoplasm]' HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8953518] Jassal, Bijay, 2016-12-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8866601
summation
[Summation:8866626] SAMHD1:Zn2+ tetramer (Deoxynucleoside triphosphate triphosph...
updateTrackers
[UpdateTracker:9775588] Update Tracker - [Reaction:8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - v78:[addOutput]
Referrals
(updatedInstance)
[UpdateTracker:9775588] Update Tracker - [Reaction:8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - v78:[addOutput]
(hasEvent)
[Pathway:R-HSA-8956319] Nucleotide catabolism
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text