Reactome | HSPG2(22-4391) [extracellular region]

Schema > EntityWithAccessionedSequence > Entries

HSPG2(22-4391) [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-2426324] HSPG2:Dystroglycan [plasma membrane] - Homo sapiens [Complex:R-HSA-4084512] Laminins with alpha-1, -2 or -5:HSPG2(22-4391) [extracellular region] - Homo sapiens [Complex:R-HSA-977084] Amyloid fibrils [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2396395] HSPG2 (perlecan) binds alpha-dystroglycan - Homo sapiens [Reaction:R-HSA-2396337] HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer - Homo sapiens [Reaction:R-NUL-2534170] Degradation of HSPG2 by Mmp13 and Ctss - Homo sapiens [Reaction:R-HSA-2534160] HSPG2 (perlecan) degradation by MMP13, CTSS - Homo sapiens [Reaction:R-HSA-1592314] HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) - Homo sapiens [Reaction:R-HSA-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 - Homo sapiens [Reaction:R-HSA-2534240] HSPG2 (perlecan) degradation by MMP14, MMP15 - Homo sapiens [Reaction:R-HSA-2426530] Laminins:Nidogens binds HSPG2 - Homo sapiens [Reaction:R-HSA-4084505] Laminins bind HSPG2 - Homo sapiens [Reaction:R-HSA-976734] Amyloid fibrils have additional components - Homo sapiens
created	[InstanceEdit:1011571] Jupe, S, 2010-11-11
dbId	1011570
displayName	HSPG2(22-4391) [extracellular region]
endCoordinate	4391
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-DME-1011570] DIP-delta [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-2] DIP-beta [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-3] CT35293 [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-4] Nrg [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-5] Lac [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-6] elff [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-7] DIP-lambda [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-8] DIP-kappa [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-9] DIP-gamma [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-10] DIP-zeta [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-11] DIP-theta [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-12] fipi [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1011570-13] DIP-alpha [extracellular region] - Drosophila melanogaster [DefinedSet:R-DME-1011570-14] Homologues of HSPG2(22-4391) [extracellular region] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-1011570] rig-5 [extracellular region] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-1011570-2] HSPG2(22-4391) [extracellular region] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-1011570-3] lad-2 [extracellular region] - Caenorhabditis elegans [DefinedSet:R-CEL-1011570-4] Homologues of HSPG2(22-4391) [extracellular region] - Caenorhabditis elegans
maxDepth	1
memberOf	[DefinedSet:R-HSA-2426293] AGRN, HSPG2 [extracellular region] - Homo sapiens
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	HSPG2(22-4391) HSPG2 Perlecan Basement membrane-specific heparan sulfate proteoglycan core protein
referenceEntity	[ReferenceGeneProduct:uniprot:P98160] UniProt:P98160 HSPG2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1011570
startCoordinate	22
updateTrackers	[UpdateTracker:9873312] Update Tracker - [EntityWithAccessionedSequence:1011570] HSPG2(22-4391) [extracellular region] - v42:[modifyName] [UpdateTracker:9886731] Update Tracker - [EntityWithAccessionedSequence:1011570] HSPG2(22-4391) [extracellular region] - v45:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9873312] Update Tracker - [EntityWithAccessionedSequence:1011570] HSPG2(22-4391) [extracellular region] - v42:[modifyName] [UpdateTracker:9886731] Update Tracker - [EntityWithAccessionedSequence:1011570] HSPG2(22-4391) [extracellular region] - v45:[addName]
(hasComponent)	[Complex:R-HSA-2426324] HSPG2:Dystroglycan [plasma membrane] [Complex:R-HSA-2426668] HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] [Complex:R-HSA-2426291] Laminins with gamma-1, gamma-3:Nidogens:HSPG2 [extracellular region] [Complex:R-HSA-4084512] Laminins with alpha-1, -2 or -5:HSPG2(22-4391) [extracellular region] [Complex:R-HSA-977084] Amyloid fibrils [plasma membrane]
(input)	[Reaction:R-HSA-2396395] HSPG2 (perlecan) binds alpha-dystroglycan [Reaction:R-HSA-2396337] HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [Reaction:R-NUL-2534170] Degradation of HSPG2 by Mmp13 and Ctss [Reaction:R-HSA-2534160] HSPG2 (perlecan) degradation by MMP13, CTSS [Reaction:R-HSA-1592314] HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) [Reaction:R-HSA-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 [Reaction:R-HSA-2534240] HSPG2 (perlecan) degradation by MMP14, MMP15 [Reaction:R-HSA-2426530] Laminins:Nidogens binds HSPG2 [Reaction:R-HSA-4084505] Laminins bind HSPG2 [Reaction:R-HSA-976734] Amyloid fibrils have additional components
(hasMember)	[DefinedSet:R-HSA-2426293] AGRN, HSPG2 [extracellular region]

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