Reactome | NOTCH3 Activation and Transmission of Signal to the Nucleus

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NOTCH3 Activation and Transmission of Signal to the Nucleus Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827451
displayName	NOTCH3 Activation and Transmission of Signal to the Nucleus
eventOf	[Pathway:R-GGA-9012852] Signaling by NOTCH3 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-2168136] NOTCH3 binds DLL4 - Gallus gallus [Reaction:R-GGA-9013284] NOTCH3-ligand complex is cleaved to produce NEXT3 - Gallus gallus [Reaction:R-GGA-9013361] NEXT3 is cleaved to produce NICD3 - Gallus gallus [Pathway:R-GGA-9017802] Noncanonical activation of NOTCH3 - Gallus gallus [Reaction:R-GGA-9018573] NOTCH3 binds activated EGFR - Gallus gallus [Reaction:R-GGA-9018572] EGFR phosphorylates NOTCH3 - Gallus gallus [Reaction:R-GGA-9021520] NOTCH3 binds WWP2 - Gallus gallus [Reaction:R-GGA-9021523] WWP2 ubiquitinates NOTCH3 - Gallus gallus
inferredFrom	[Pathway:R-HSA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	NOTCH3 Activation and Transmission of Signal to the Nucleus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-9013507
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9012852] Signaling by NOTCH3
(inferredTo)	[Pathway:R-HSA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus

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