Reactome | NOTCH3-ligand complex is cleaved to produce NEXT3

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NOTCH3-ligand complex is cleaved to produce NEXT3 Show undefined attributes

catalystActivity	[CatalystActivity:10814665] metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10814667
displayName	NOTCH3-ligand complex is cleaved to produce NEXT3
eventOf	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9013361] NEXT3 is cleaved to produce NICD3 - Gallus gallus [Reaction:R-GGA-9021520] NOTCH3 binds WWP2 - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:937686] Notch receptor processing, ligand-dependent
inferredFrom	[Reaction:R-HSA-9013284] NOTCH3-ligand complex is cleaved to produce NEXT3 - Homo sapiens
input	[DefinedSet:R-GGA-9013089] Ub-DLL/JAG:NOTCH3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NOTCH3-ligand complex is cleaved to produce NEXT3
output	[EntityWithAccessionedSequence:R-GGA-157203] NEXT3 [plasma membrane] [DefinedSet:R-GGA-9013287] Ub-DLL/JAG:NOTCH3(40-1628) [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9013284
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-GGA-9021520] NOTCH3 binds WWP2 [Reaction:R-GGA-9013361] NEXT3 is cleaved to produce NICD3
(inferredTo)	[Reaction:R-HSA-9013284] NOTCH3-ligand complex is cleaved to produce NEXT3

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