Reactome | NOTCH3 binds WWP2

Schema > Reaction > Entries

NOTCH3 binds WWP2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10815300
displayName	NOTCH3 binds WWP2
eventOf	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9021523] WWP2 ubiquitinates NOTCH3 - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
inferredFrom	[Reaction:R-HSA-9021520] NOTCH3 binds WWP2 - Homo sapiens
input	[DefinedSet:R-GGA-9021530] NEXT3,NICD3 [cytosol] [EntityWithAccessionedSequence:R-GGA-6807279] WWP2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NOTCH3 binds WWP2
output	[Complex:R-GGA-9021521] NEXT3,NICD3:WWP2 [cytosol]
precedingEvent	[Reaction:R-GGA-9013361] NEXT3 is cleaved to produce NICD3 - Gallus gallus [Reaction:R-GGA-9013284] NOTCH3-ligand complex is cleaved to produce NEXT3 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9021520
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-GGA-9021523] WWP2 ubiquitinates NOTCH3
(inferredTo)	[Reaction:R-HSA-9021520] NOTCH3 binds WWP2