Reactome | NOTCH3 binds activated EGFR

Schema > Reaction > Entries

NOTCH3 binds activated EGFR Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10814878
displayName	NOTCH3 binds activated EGFR
eventOf	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9018572] EGFR phosphorylates NOTCH3 - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
inferredFrom	[Reaction:R-HSA-9018573] NOTCH3 binds activated EGFR - Homo sapiens
input	[Complex:R-GGA-179882] EGF:p-6Y-EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-GGA-157647] NICD3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NOTCH3 binds activated EGFR
output	[Complex:R-GGA-9018569] EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
precedingEvent	[Reaction:R-GGA-177934] EGFR autophosphorylation - Gallus gallus [Reaction:R-GGA-9013361] NEXT3 is cleaved to produce NICD3 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9018573
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-GGA-9018572] EGFR phosphorylates NOTCH3
(inferredTo)	[Reaction:R-HSA-9018573] NOTCH3 binds activated EGFR

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