Reactome | NOTCH3 binds DLL4

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10780305
displayName	NOTCH3 binds DLL4
eventOf	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
inferredFrom	[Reaction:R-HSA-2168136] NOTCH3 binds DLL4 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-158437] DLL4 [plasma membrane] [Complex:R-GGA-157048] NOTCH3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NOTCH3 binds DLL4
output	[Complex:R-GGA-2168132] DLL4:NOTCH3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2168136
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(inferredTo)	[Reaction:R-HSA-2168136] NOTCH3 binds DLL4