Reactome | Binding of GRB2 to GAB1

Schema > Reaction > Entries

Binding of GRB2 to GAB1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10744276
displayName	Binding of GRB2 to GAB1
eventOf	[Pathway:R-GGA-180292] GAB1 signalosome - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Gallus gallus [Reaction:R-GGA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Gallus gallus [Reaction:R-GGA-177941] GRB2:GAB1 binds to phosphorylated EGFR - Gallus gallus
inferredFrom	[Reaction:R-HSA-177920] Binding of GRB2 to GAB1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-179795] GAB1 [cytosol] [EntityWithAccessionedSequence:R-GGA-74686] GRB2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of GRB2 to GAB1
output	[Complex:R-GGA-179849] GRB2:GAB1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-177920
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-180292] GAB1 signalosome
(precedingEvent)	[Reaction:R-GGA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Reaction:R-GGA-177941] GRB2:GAB1 binds to phosphorylated EGFR [Reaction:R-GGA-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
(inferredTo)	[Reaction:R-HSA-177920] Binding of GRB2 to GAB1