Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6

Stable Identifier
R-GGA-451470
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
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TRAF6 generates unanchored Lys63-linked polyubiquitin chains that bind to the regulatory subunits of the TAK1 (TAB2 or TAB3), leading to the activation of TAK1[Xia et al. 2009].

Literature References
PubMed ID Title Journal Year
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A, Xu, M, Chen, ZJ

Oncogene 2007
14633987 Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

Ishitani, T, Takaesu, G, Ninomiya-Tsuji, J, Shibuya, H, Gaynor, RB, Matsumoto, K

EMBO J 2003
15836773 TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

Kishida, S, Sanjo, H, Akira, S, Matsumoto, K, Ninomiya-Tsuji, J

Genes Cells 2005
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ

Nature 2009
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Catalyst Activity
Title
ubiquitin-protein transferase activity of oligo TRAF6 : p-IRAK2 [plasma membrane]
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