IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88

Stable Identifier
R-GGA-433864
Type
Reaction [binding]
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.

Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.

Literature References
PubMed ID Title Journal Year
19539094 The avian Toll-Like receptor pathway--subtle differences amidst general conformity

Cormican, P, Lloyd, AT, Downing, T, Connell, SJ, Bradley, D, O'Farrelly, C

Dev Comp Immunol 2009
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S

Nat Immunol 2008
Participants
Participant Of
Inferred From
Authored
Reviewed
Created