Reactome | 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate

Schema > Reaction > Entries

5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate Show undefined attributes

authored	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
catalystActivity	[CatalystActivity:419257] (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity of ADSL [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:419263] D'Eustachio, P, 2009-04-29 19:22:36
dbId	419255
displayName	5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
edited	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
eventOf	[Pathway:R-GGA-419140] De novo synthesis of IMP - Gallus gallus
followingEvent	[Reaction:R-GGA-419254] 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate - Gallus gallus
input	[SimpleEntity:R-ALL-111399] SAICAR [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:419246] Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
output	[SimpleEntity:R-ALL-111409] AICAR [cytosol] [SimpleEntity:R-ALL-29586] FUMA [cytosol]
precedingEvent	[Reaction:R-GGA-419223] 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate - Gallus gallus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-419255
summation	[Summation:419250] The adenylosuccinate lyase activity of cytosolic ADSL (adeny...

Referrals

(hasEvent)	[Pathway:R-GGA-419140] De novo synthesis of IMP
(precedingEvent)	[Reaction:R-GGA-419254] 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate

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