Reactome | 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate

Schema > Reaction > Entries

5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate Show undefined attributes

authored	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
catalystActivity	[CatalystActivity:419247] phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:419263] D'Eustachio, P, 2009-04-29 19:22:36
dbId	419254
displayName	5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
edited	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
eventOf	[Pathway:R-GGA-419140] De novo synthesis of IMP - Gallus gallus
followingEvent	[Reaction:R-GGA-419253] 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O - Gallus gallus
input	[SimpleEntity:R-ALL-419151] 10-formyl-THF [cytosol] [SimpleEntity:R-ALL-111409] AICAR [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:419249] On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver [LiteratureReference:419252] Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
output	[SimpleEntity:R-ALL-111427] FAICAR [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-GGA-419255] 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate - Gallus gallus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-419254
summation	[Summation:419251] The phosphoribosylaminoimidazolecarboxamide formyltransferas...

Referrals

(hasEvent)	[Pathway:R-GGA-419140] De novo synthesis of IMP
(precedingEvent)	[Reaction:R-GGA-419253] 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O

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