5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate

Stable Identifier
R-GGA-419255
Type
Reaction [transition]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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The adenylosuccinate lyase activity of cytosolic ADSL (adenylosuccinate lyase) catalyzes the reaction of 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) to form 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and fumarate. A Chicken ADSL cDNA has been identified on the basis of its ability to complement an E. coli strain mutated in the homologous gene (Aime et al. 1990). The chicken protein has not been characterized in detail. Its active form is annotated here arbitrarily as a monomer and its cytosolic localization is inferred from that of its better-characterized mammalian counterparts.

Literature References
PubMed ID Title Journal Year
2111814 Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli

Zalkin, H, Aimi, J, Williams, J, Badylak, J, Chen, ZD, Dixon, JE

J Biol Chem 1990
Participants
Participates
Catalyst Activity

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity of ADSL [cytosol]

Authored
Created
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