Reactome | De novo synthesis of IMP

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De novo synthesis of IMP Show undefined attributes

authored	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:419136] D'Eustachio, P, 2009-04-28 21:22:12
dbId	419140
displayName	De novo synthesis of IMP
edited	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
eventOf	[Pathway:R-GGA-419474] Purine metabolism - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:16157] 'de novo' IMP biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-420911] Formation of PPAT dimers - Gallus gallus [Reaction:R-GGA-420906] Formation of PPAT tetramers - Gallus gallus [Reaction:R-GGA-419152] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate - Gallus gallus [Reaction:R-GGA-419153] 5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate - Gallus gallus [Reaction:R-GGA-419145] 5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate - Gallus gallus [Reaction:R-GGA-419144] 5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate - Gallus gallus [Reaction:R-GGA-419157] 5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate - Gallus gallus [Reaction:R-GGA-419214] 5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) - Gallus gallus [Reaction:R-GGA-419223] 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate - Gallus gallus [Reaction:R-GGA-419255] 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate - Gallus gallus [Reaction:R-GGA-419254] 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate - Gallus gallus [Reaction:R-GGA-419253] 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O - Gallus gallus
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111329] De novo purine nucleotide biosynthesis
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	De novo synthesis of IMP
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-419140
summation	[Summation:419142] The purine ribonucleotide inosine 5'-monophosphate (IMP) is ...

Referrals

(hasEvent)

[Pathway:R-GGA-419474] Purine metabolism

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