Reactome | DHFR dimer binds DHFR inhibitors

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10818371
displayName	DHFR dimer binds DHFR inhibitors
eventOf	[Pathway:R-GGA-196757] Metabolism of folate and pterines - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9709109] DHFR dimer binds DHFR inhibitors - Homo sapiens
input	[Complex:R-GGA-1497822] DHFR dimer [cytosol] [DefinedSet:R-ALL-9709140] DHFR inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DHFR dimer binds DHFR inhibitors
output	[Complex:R-GGA-9709105] DHFR dimer:DHFR inhibitors [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9709109
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-196757] Metabolism of folate and pterines
(inferredTo)	[Reaction:R-HSA-9709109] DHFR dimer binds DHFR inhibitors

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