Reactome | MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG

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MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10747977] methylenetetrahydrofolate dehydrogenase (NADP+) activity of MTHFD1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10748026
displayName	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG
eventOf	[Pathway:R-GGA-196757] Metabolism of folate and pterines - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Gallus gallus
inferredFrom	[Reaction:R-HSA-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-200640] 5,10-methenyl-THFPG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG 5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+
output	[SimpleEntity:R-ALL-200739] 5,10-methylene-THFPG [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-GGA-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-200718
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-GGA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
(inferredTo)	[Reaction:R-HSA-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG

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