Reactome | FOLR2 transports FOLA from extracellular region to cytosol

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FOLR2 transports FOLA from extracellular region to cytosol Show undefined attributes

category	omitted
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10810746
displayName	FOLR2 transports FOLA from extracellular region to cytosol
eventOf	[Pathway:R-GGA-196757] Metabolism of folate and pterines - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:22593] receptor-mediated endocytosis
inferredFrom	[BlackBoxEvent:R-HSA-8942344] FOLR2 transports FOLA from extracellular region to cytosol - Homo sapiens
input	[Complex:R-GGA-8940118] FOLR2:FOLA [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FOLR2 transports FOLA from extracellular region to cytosol
output	[SimpleEntity:R-ALL-197965] FOLA [cytosol] [DefinedSet:R-GGA-8940133-3] Homologues of FOLR2 [plasma membrane]
precedingEvent	[Reaction:R-GGA-8940134] FOLR2 binds FOLA - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-8942344
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-196757] Metabolism of folate and pterines
(inferredTo)	[BlackBoxEvent:R-HSA-8942344] FOLR2 transports FOLA from extracellular region to cytosol

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