Reactome | Recruitment and activation of Chk1

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Recruitment and activation of Chk1 Show undefined attributes

catalystActivity	[CatalystActivity:10743993] protein serine/threonine kinase activity of ATR:ATRIP [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10743995
displayName	Recruitment and activation of Chk1
eventOf	[Pathway:R-GGA-69473] G2/M DNA damage checkpoint - Gallus gallus [Pathway:R-GGA-176187] Activation of ATR in response to replication stress - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-69604] Phosphorylation of CDC25A by CHEK1 - Gallus gallus [BlackBoxEvent:R-GGA-9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
inferredFrom	[Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-113826] CHEK1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment and activation of Chk1
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-113838] phospho-p-S317,S345-CHEK1 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-176298] Activation of claspin - Gallus gallus [Reaction:R-GGA-176264] Recruitment of the Rad9-Hus1-Rad1 complex to DNA - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-176116
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-176187] Activation of ATR in response to replication stress [Pathway:R-GGA-69473] G2/M DNA damage checkpoint
(precedingEvent)	[BlackBoxEvent:R-GGA-9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A [Reaction:R-GGA-69604] Phosphorylation of CDC25A by CHEK1
(inferredTo)	[Reaction:R-HSA-176116] Recruitment and activation of Chk1