Reactome | phospho-p-S317,S345-CHEK1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10733227] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10733226
displayName	phospho-p-S317,S345-CHEK1 [nucleoplasm]
endCoordinate	476
hasModifiedResidue	[ModifiedResidue:10733224] O-phospho-L-serine at 317 (in Homo sapiens) [ModifiedResidue:217221] O-phospho-L-serine at 345
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-113838] p-S317,S345-CHEK1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-p-S317,S345-CHEK1 Q8AYC9
producedByEvent	[Reaction:R-GGA-176116] Recruitment and activation of Chk1 - Gallus gallus [Reaction:R-GGA-5684887] Activation of CHEK1 at resected DNA DSBs - Gallus gallus
referenceEntity	[ReferenceGeneProduct:uniprot:Q8AYC9] UniProt:Q8AYC9 CHEK1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49591] Gallus gallus
stId	R-GGA-113838
startCoordinate	1

(output)	[Reaction:R-GGA-176116] Recruitment and activation of Chk1 [Reaction:R-GGA-5684887] Activation of CHEK1 at resected DNA DSBs
(physicalEntity)	[CatalystActivity:10733227] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-113838] p-S317,S345-CHEK1 [nucleoplasm]

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