Reactome | Activation of claspin

Schema > Reaction > Entries

Activation of claspin Show undefined attributes

catalystActivity	[CatalystActivity:10743993] protein serine/threonine kinase activity of ATR:ATRIP [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10744039
displayName	Activation of claspin
eventOf	[Pathway:R-GGA-176187] Activation of ATR in response to replication stress - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-176116] Recruitment and activation of Chk1 - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
inferredFrom	[Reaction:R-HSA-176298] Activation of claspin - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-176229] Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of claspin
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-GGA-176182] Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm]
precedingEvent	[Reaction:R-GGA-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex - Gallus gallus [Reaction:R-GGA-176318] Loading of claspin onto DNA during replication origin firing - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-176298
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-176187] Activation of ATR in response to replication stress
(precedingEvent)	[Reaction:R-GGA-176116] Recruitment and activation of Chk1
(inferredTo)	[Reaction:R-HSA-176298] Activation of claspin