Reactome | MEKK1 binds TRAF6

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MEKK1 binds TRAF6 Show undefined attributes

authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
category	binding
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:1227772] Shamovsky, V, 2011-03-10
dbId	1227778
displayName	MEKK1 binds TRAF6
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
eventOf	[Pathway:R-GGA-1227892] TRAF6 mediated NF-kB activation - Gallus gallus
followingEvent	[Reaction:R-GGA-1227783] Phosphorylation of IKKs complex mediated by MEKK1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-933528] Interaction of MEKK1 with TRAF6 - Homo sapiens
input	[DefinedSet:R-GGA-1227773] dsRNA:MDA5:IPS1:K63-linked pUb TRAF6 or TRAF2 [mitochondrial outer membrane] 2 × [EntityWithAccessionedSequence:R-GGA-1227800] MEKK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:933430] TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway [LiteratureReference:165931] MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MEKK1 binds TRAF6
output	[Complex:R-GGA-1227776] dsRNA:MDA5:IPS1:K63-pUb-TRAF6/or TRAF2:MEKK1 [mitochondrial outer membrane]
precedingEvent	[BlackBoxEvent:R-GGA-1227769] TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex - Gallus gallus
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1227778
summation	[Summation:1267833] Mammalian MEKK1 was reported to be involved to IPS-1/TRAF6 s...

Referrals

(hasEvent)	[Pathway:R-GGA-1227892] TRAF6 mediated NF-kB activation
(precedingEvent)	[Reaction:R-GGA-1227783] Phosphorylation of IKKs complex mediated by MEKK1
(inferredTo)	[Reaction:R-HSA-933528] Interaction of MEKK1 with TRAF6

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