MEKK1 binds TRAF6

Stable Identifier
R-GGA-1227778
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
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Mammalian MEKK1 was reported to be involved to IPS-1/TRAF6 signaling pathway leading to NFkB activation, however the mechanism of virus-triggered MEKK1 activation remains unclear.

Predicted chicken MEKK1 shows 77% amino acid sequence identity to its human counterpart.

Literature References
PubMed ID Title Journal Year
18984593 TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway

Yoshida, R, Takaesu, G, Yoshida, H, Okamoto, F, Yoshioka, T, Choi, Y, Akira, S, Kawai, T, Yoshimura, A, Kobayashi, T

J Biol Chem 2008
9689078 MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

Lee, FS, Peters, RT, Dang, LC, Maniatis, T

Proc Natl Acad Sci U S A 1998
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