Reactome | TRAF6 mediated NF-kB activation

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TRAF6 mediated NF-kB activation Show undefined attributes

authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
created	[InstanceEdit:1227896] Shamovsky, V, 2011-03-10
dbId	1227892
displayName	TRAF6 mediated NF-kB activation
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
eventOf	[Pathway:R-GGA-1227887] RLR (RIG-like receptor) mediated induction of IFN alpha/beta - Gallus gallus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-1227775] TRAF6/or TRAF2 interacts with IPS-1 - Gallus gallus [BlackBoxEvent:R-GGA-1227769] TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex - Gallus gallus [Reaction:R-GGA-1227778] MEKK1 binds TRAF6 - Gallus gallus [Reaction:R-GGA-1227783] Phosphorylation of IKKs complex mediated by MEKK1 - Gallus gallus [Reaction:R-GGA-433986] activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB - Gallus gallus
isInDisease	false
isInferred	false
lastUpdatedDate	2011-12-31
literatureReference	[LiteratureReference:918176] VISA is an adapter protein required for virus-triggered IFN-beta signaling
maxDepth	2
modified	[InstanceEdit:9856144] Shamovsky, Veronica, 2023-12-12
name	TRAF6 mediated NF-kB activation
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-1227892
summation	[Summation:1237365] TNF receptor associated factor (TRAF) protein family members... [Summation:1267770] Although RLR-mediated signaling to NFkB and MAPK shares simi...
updateTrackers	[UpdateTracker:9789047] Update Tracker - [Pathway:1227892] TRAF6 mediated NF-kB activation - v39:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9789047] Update Tracker - [Pathway:1227892] TRAF6 mediated NF-kB activation - v39:[updateContainedRLE]
(hasEvent)	[Pathway:R-GGA-1227887] RLR (RIG-like receptor) mediated induction of IFN alpha/beta

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