Reactome | EPH-Ephrin signaling

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EPH-Ephrin signaling Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912686
displayName	EPH-Ephrin signaling
eventOf	[Pathway:R-DME-422475] Axon guidance - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:186] ephrin receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-3928646] EPHAs bind EFNAs - Drosophila melanogaster [Reaction:R-DME-3928624] EPHBs bind EFNBs - Drosophila melanogaster [Reaction:R-DME-3928597] EPH:EFN dimers tetramerise - Drosophila melanogaster [Polymerisation:R-DME-3928591] EPH:EFN tetramers oligomerise - Drosophila melanogaster [Reaction:R-DME-3928578] EPH receptors autophosphorylate - Drosophila melanogaster [Pathway:R-DME-3928663] EPHA-mediated growth cone collapse - Drosophila melanogaster [Pathway:R-DME-3928662] EPHB-mediated forward signaling - Drosophila melanogaster [Pathway:R-DME-3928664] Ephrin signaling - Drosophila melanogaster [Pathway:R-DME-3928665] EPH-ephrin mediated repulsion of cells - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-2682334] EPH-Ephrin signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	EPH-Ephrin signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2682334
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-DME-1483255] PI Metabolism
(hasEvent)	[Pathway:R-DME-422475] Axon guidance
(inferredTo)	[Pathway:R-HSA-2682334] EPH-Ephrin signaling