Reactome | EPHA-mediated growth cone collapse

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912692
displayName	EPHA-mediated growth cone collapse
eventOf	[Pathway:R-DME-2682334] EPH-Ephrin signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-3928651] NGEF exchanges GTP for GDP on RHOA - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-3928663] EPHA-mediated growth cone collapse - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	EPHA-mediated growth cone collapse
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3928663
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-2682334] EPH-Ephrin signaling
(inferredTo)	[Pathway:R-HSA-3928663] EPHA-mediated growth cone collapse

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