Reactome | EPHB-mediated forward signaling

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EPHB-mediated forward signaling Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912684
displayName	EPHB-mediated forward signaling
eventOf	[Pathway:R-DME-2682334] EPH-Ephrin signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-3928601] CDC42 and PIP2 bind WASL, activating it - Drosophila melanogaster [Reaction:R-DME-3928595] N-WASP binds ARP2/3 and G-actin - Drosophila melanogaster [Reaction:R-DME-3928617] EPHB2 binds KALRN - Drosophila melanogaster [Reaction:R-DME-3928612] KALRN exchanges GTP for GDP on RAC1, activating it - Drosophila melanogaster [Reaction:R-DME-3928619] PAK1 binds RAC1:GTP - Drosophila melanogaster [Reaction:R-DME-3928620] PAK1 autophosphorylates - Drosophila melanogaster [Reaction:R-DME-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it - Drosophila melanogaster [Reaction:R-DME-3928576] RHOA:GTP binds ROCK, activating it - Drosophila melanogaster [Reaction:R-DME-3928645] EPHB:NMDAR binds TIAM1 - Drosophila melanogaster [Reaction:R-DME-3928627] EPHB phosphorylates TIAM1 - Drosophila melanogaster [Reaction:R-DME-4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it - Drosophila melanogaster [Reaction:R-DME-4093331] Ras:GTP binds p120-RasGAP - Drosophila melanogaster [Reaction:R-DME-4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it - Drosophila melanogaster [Reaction:R-DME-4093332] p-EPHB phosphorylates SDC2 - Drosophila melanogaster [BlackBoxEvent:R-DME-4093342] SDC2 multimerises - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-3928662] EPHB-mediated forward signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	EPHB-mediated forward signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3928662
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2682334] EPH-Ephrin signaling
(inferredTo)	[Pathway:R-HSA-3928662] EPHB-mediated forward signaling

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