Reactome | EPHAs bind EFNAs

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10874848
displayName	EPHAs bind EFNAs
eventOf	[Pathway:R-DME-2682334] EPH-Ephrin signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-3928597] EPH:EFN dimers tetramerise - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-3928646] EPHAs bind EFNAs - Homo sapiens
input	[DefinedSet:R-DME-3928348] EPHAs [plasma membrane] [EntityWithAccessionedSequence:R-DME-2682339] Ephrin [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	EPHAs bind EFNAs Ephrin-A ligands interacts with EPHA receptors
output	[Complex:R-DME-3928330] EPHAs:EFNAs [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3928646
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-2682334] EPH-Ephrin signaling
(precedingEvent)	[Reaction:R-DME-3928597] EPH:EFN dimers tetramerise
(inferredTo)	[Reaction:R-HSA-3928646] EPHAs bind EFNAs

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