Reactome | The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

Schema > Reaction > Entries

The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle Show undefined attributes

catalystActivity	[CatalystActivity:10862824] tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10862826
displayName	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
eventOf	[Pathway:R-DME-203615] eNOS activation - Drosophila melanogaster [Pathway:R-DME-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Drosophila melanogaster [Pathway:R-DME-5218920] VEGFR2 mediated vascular permeability - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-202127] eNOS synthesizes NO - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Homo sapiens
input	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [Complex:R-DME-202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
output	[Complex:R-DME-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
precedingEvent	[Reaction:R-DME-202111] AKT1 phosphorylates eNOS - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1497784
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5218920] VEGFR2 mediated vascular permeability [Pathway:R-DME-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation [Pathway:R-DME-203615] eNOS activation
(precedingEvent)	[Reaction:R-DME-202127] eNOS synthesizes NO
(inferredTo)	[Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

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