Reactome | DNA nucleases bind monoubiquitinated ID2 complex

Schema > Reaction > Entries

DNA nucleases bind monoubiquitinated ID2 complex Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10298784
displayName	DNA nucleases bind monoubiquitinated ID2 complex
eventOf	[Pathway:R-CFA-6783310] Fanconi Anemia Pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-6785986] DNA nucleases unhook the interstrand crosslink (ICL) - Canis familiaris
inferredFrom	[Reaction:R-HSA-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Homo sapiens
input	[CandidateSet:R-CFA-6785737] DCLRE1A,DCLRE1B [nucleoplasm] [Complex:R-CFA-109943] ERCC1:ERCC4 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-CFA-6785736] FAN1 [nucleoplasm] [Complex:R-CFA-6785367] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] [Complex:R-CFA-5686474] SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DNA nucleases bind monoubiquitinated ID2 complex
output	[Complex:R-CFA-6785734] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm]
regulatedBy	[NegativeRegulation:10298785] Negative regulation by 'USP1:WDR48 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6785732
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6783310] Fanconi Anemia Pathway
(precedingEvent)	[BlackBoxEvent:R-CFA-6785986] DNA nucleases unhook the interstrand crosslink (ICL)
(inferredTo)	[Reaction:R-HSA-6785732] DNA nucleases bind monoubiquitinated ID2 complex