Reactome | FA core complex assembles at DNA interstrand crosslinks (ICLs)

Schema > Reaction > Entries

FA core complex assembles at DNA interstrand crosslinks (ICLs) Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10298695
displayName	FA core complex assembles at DNA interstrand crosslinks (ICLs)
eventOf	[Pathway:R-CFA-6783310] Fanconi Anemia Pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6785126] FA core complex assembles at DNA interstrand crosslinks (ICLs) - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-419545] FAAP100 [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-6783321] FAAP20 [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-419541] FANCA [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-419528] FANCB [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-419530] FANCC [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-419543] FANCE [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-419537] FANCF [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-419532] FANCG [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-419520] FANCL [nucleoplasm] [Complex:R-CFA-6785090] FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	FA core complex assembles at DNA interstrand crosslinks (ICLs)
output	[Complex:R-CFA-6785124] FA Core Complex:ICL-DNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6785126
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6783310] Fanconi Anemia Pathway
(inferredTo)	[Reaction:R-HSA-6785126] FA core complex assembles at DNA interstrand crosslinks (ICLs)

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