Reactome | The complex of ATR and ATRIP is recruited to ICL-DNA

Schema > Reaction > Entries

The complex of ATR and ATRIP is recruited to ICL-DNA Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10299167
displayName	The complex of ATR and ATRIP is recruited to ICL-DNA
eventOf	[Pathway:R-CFA-6783310] Fanconi Anemia Pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Canis familiaris
inferredFrom	[Reaction:R-HSA-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Homo sapiens
input	[Complex:R-CFA-176269] ATR:ATRIP [nucleoplasm] [Complex:R-CFA-6785340] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] [Complex:R-CFA-68462] RPA heterotrimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	The complex of ATR and ATRIP is recruited to ICL-DNA
output	[Complex:R-CFA-6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6788385
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6783310] Fanconi Anemia Pathway
(precedingEvent)	[Reaction:R-CFA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
(inferredTo)	[Reaction:R-HSA-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA

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