Reactome | Interaction of SOS-1 to Tie2 bound Grb2

Schema > Reaction > Entries

Interaction of SOS-1 to Tie2 bound Grb2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10247373
displayName	Interaction of SOS-1 to Tie2 bound Grb2
eventOf	[Pathway:R-CFA-210993] Tie2 Signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) - Canis familiaris [Reaction:R-CFA-5672965] RAS GEFs promote RAS nucleotide exchange - Canis familiaris
inferredFrom	[Reaction:R-HSA-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Homo sapiens
input	[Complex:R-CFA-204865] Grb2 bound to Tie2 [plasma membrane] [EntityWithAccessionedSequence:R-CFA-64847] SOS1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of SOS-1 to Tie2 bound Grb2
output	[Complex:R-CFA-210970] SOS-1 bound to Tie2:Grb2 [plasma membrane]
precedingEvent	[Reaction:R-CFA-204871] Interaction of Tie2 and Grb2 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-210974
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-210993] Tie2 Signaling
(precedingEvent)	[Reaction:R-CFA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) [Reaction:R-CFA-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-210974] Interaction of SOS-1 to Tie2 bound Grb2

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