Reactome | RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET

Schema > Reaction > Entries

RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET Show undefined attributes

catalystActivity	[CatalystActivity:10307140] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10307142
displayName	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
eventOf	[Pathway:R-CFA-8851805] MET activates RAS signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5672965] RAS GEFs promote RAS nucleotide exchange - Canis familiaris
inferredFrom	[Reaction:R-HSA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-CFA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-CFA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-CFA-8851900] SHC1-2 bound to MET recruits GRB2:SOS1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8851899
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8851805] MET activates RAS signaling
(precedingEvent)	[Reaction:R-CFA-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET

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