Reactome | p-ERK phosphorylates WAVEs and ABI

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p-ERK phosphorylates WAVEs and ABI Show undefined attributes

catalystActivity	[CatalystActivity:10275606] protein serine/threonine kinase activity of p-T,Y MAPK dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10275608
displayName	p-ERK phosphorylates WAVEs and ABI
eventOf	[Pathway:R-CFA-5663213] RHO GTPases Activate WASPs and WAVEs - Canis familiaris [Pathway:R-CFA-2029482] Regulation of actin dynamics for phagocytic cup formation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2029469] p-ERK phosphorylates WAVEs and ABI - Homo sapiens
input	8 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-2130182] p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-ERK phosphorylates WAVEs and ABI
output	8 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-2029148] p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol]
precedingEvent	[Reaction:R-CFA-2130194] ABL phosphorylates WAVEs - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2029469
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5663213] RHO GTPases Activate WASPs and WAVEs [Pathway:R-CFA-2029482] Regulation of actin dynamics for phagocytic cup formation
(inferredTo)	[Reaction:R-HSA-2029469] p-ERK phosphorylates WAVEs and ABI