Reactome | Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere

Schema > Reaction > Entries

Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere Show undefined attributes

catalystActivity	[CatalystActivity:10239973] DNA clamp loader activity of RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10239975
displayName	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
eventOf	[Pathway:R-CFA-174411] Polymerase switching on the C-strand of the telomere - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-174447] RFC dissociates after sliding clamp formation on the C-strand of the telomere - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
inferredFrom	[Reaction:R-HSA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-CFA-68440] PCNA homotrimer [nucleoplasm] [Complex:R-CFA-174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-CFA-174449] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm]
precedingEvent	[Reaction:R-CFA-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-174439
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-174411] Polymerase switching on the C-strand of the telomere
(precedingEvent)	[Reaction:R-CFA-174447] RFC dissociates after sliding clamp formation on the C-strand of the telomere
(inferredTo)	[Reaction:R-HSA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere

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