Reactome | Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere

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Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere Show undefined attributes

authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
catalystActivity	[CatalystActivity:9668886] DNA clamp loader activity of RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
dbId	174439
displayName	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
eventOf	[Pathway:R-HSA-174411] Polymerase switching on the C-strand of the telomere - Homo sapiens
followingEvent	[Reaction:R-HSA-174447] RFC dissociates after sliding clamp formation on the C-strand of the telomere - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-HSA-68440] PCNA homotrimer [nucleoplasm] [Complex:R-HSA-174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9668885] DNA polymerase ? stalls on telomeric lagging strand templates independently from G-quadruplex formation [LiteratureReference:5686191] RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
negativePrecedingEvent	[NegativePrecedingEvent:9766486] Futile Cycle: Disassociation of Processive Complex and Completed Telomere End
orthologousEvent	[Reaction:R-GGA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Gallus gallus [Reaction:R-SSC-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Sus scrofa [Reaction:R-BTA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Bos taurus [Reaction:R-CFA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Canis familiaris [Reaction:R-RNO-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Rattus norvegicus [Reaction:R-MMU-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-174449] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Homo sapiens
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174439
summation	[Summation:69064] The binding of the primer recognition complex involves the l...
updateTrackers	[UpdateTracker:9776962] Update Tracker - [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - v73:[modifyText] [UpdateTracker:9777207] Update Tracker - [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - v72:[addCatalystActivity, addInput, addLiteratureReference, addOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776962] Update Tracker - [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - v73:[modifyText] [UpdateTracker:9777207] Update Tracker - [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - v72:[addCatalystActivity, addInput, addLiteratureReference, addOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-174411] Polymerase switching on the C-strand of the telomere
(precedingEvent)	[Reaction:R-HSA-174447] RFC dissociates after sliding clamp formation on the C-strand of the telomere

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