Reactome | Pyruvate metabolism

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Pyruvate metabolism Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:17927] mitochondrial intermembrane space [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10442876
displayName	Pyruvate metabolism
eventOf	[Pathway:R-BTA-1428517] Aerobic respiration and respiratory electron transport - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:81689] pyruvate biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Bos taurus [Reaction:R-BTA-71670] Pyruvate kinase dephosphorylates PEP to PYR - Bos taurus [Reaction:R-BTA-9012036] ME1 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-BTA-9861660] ME1 tetramer decarboxylates OA to PYR - Bos taurus [Reaction:R-BTA-70510] LDH tetramer oxidises LACT to PYR - Bos taurus [Reaction:R-BTA-71849] LDH tetramer reduces PYR to LACT - Bos taurus [Reaction:R-BTA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Bos taurus [Reaction:R-BTA-9012016] FAHD1 dimer hydrolyses OA to PYR - Bos taurus [Reaction:R-BTA-9012268] ME2 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-BTA-9012349] ME3 tetramer decarboxylates MAL to PYR - Bos taurus [Pathway:R-BTA-9861559] PDH complex synthesizes acetyl-CoA from PYR - Bos taurus [Pathway:R-BTA-9861718] Regulation of pyruvate metabolism - Bos taurus [Reaction:R-BTA-70501] PC carboxylates PYR to OA - Bos taurus [Reaction:R-BTA-5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH - Bos taurus [Reaction:R-BTA-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT - Bos taurus
inferredFrom	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Pyruvate metabolism Cori Cycle (interconversion of glucose and lactate)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-70268
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-BTA-70326] Glucose metabolism [Pathway:R-BTA-71403] Citric acid cycle (TCA cycle) [Pathway:R-BTA-9857492] Protein lipoylation [Pathway:R-BTA-389661] Glyoxylate metabolism and glycine degradation
(inferredTo)	[Pathway:R-HSA-70268] Pyruvate metabolism
(hasEvent)	[Pathway:R-BTA-1428517] Aerobic respiration and respiratory electron transport

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