Reactome | KDSR reduces 3-ketosphingoid

Schema > Reaction > Entries

KDSR reduces 3-ketosphingoid Show undefined attributes

catalystActivity	[CatalystActivity:10363555] 3-dehydrosphinganine reductase activity of KDSR [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10363557
displayName	KDSR reduces 3-ketosphingoid
eventOf	[Pathway:R-BTA-1660661] Sphingolipid de novo biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Bos taurus [Reaction:R-BTA-9695949] SPHK2 phosphorylates sphingoid - Bos taurus [Reaction:R-BTA-428273] SPHK1 phosphorylates sphingoid - Bos taurus
inferredFrom	[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid - Homo sapiens
input	[SimpleEntity:R-ALL-9841798] 3-ketosphingoid [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	KDSR reduces 3-ketosphingoid 3-ketosphingoid + NADPH + H+ => sphingoid + NADP+
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-5279323] sphingoid base [cytoplasm]
precedingEvent	[Reaction:R-BTA-428127] SPTLC complexes transfer acyl-CoA onto serine - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-428123
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-BTA-9695949] SPHK2 phosphorylates sphingoid [Reaction:R-BTA-428273] SPHK1 phosphorylates sphingoid [Reaction:R-BTA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid
(inferredTo)	[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid