Reactome | PDK isozymes phosphorylate PDHC subunit E1

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PDK isozymes phosphorylate PDHC subunit E1 Show undefined attributes

catalystActivity	[CatalystActivity:10353220] pyruvate dehydrogenase (acetyl-transferring) kinase activity of PDK isozyme dimers [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10353224
displayName	PDK isozymes phosphorylate PDHC subunit E1
eventOf	[Pathway:R-BTA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Bos taurus [Pathway:R-BTA-5362517] Signaling by Retinoic Acid - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Bos taurus
inferredFrom	[Reaction:R-HSA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [Complex:R-BTA-70070] PDH complex [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PDK isozymes phosphorylate PDHC subunit E1 PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit Inactivation of PDC by phosphorylation of PDC E1 alpha component
output	2 × [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [Complex:R-BTA-210342] p-lipo-PDH [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Bos taurus [Reaction:R-BTA-9861667] DLAT trimer transfers acetyl to CoA - Bos taurus
regulatedBy	[Requirement:R-GGA-354223] Requirement by 'Ac-CoA [mitochondrial matrix]' [NegativeRegulation:R-HSA-210344] Negative regulation by 'PYR [mitochondrial matrix]' [PositiveRegulation:R-HSA-210348] Positive regulation by 'NADH [mitochondrial matrix]' [NegativeRegulation:10353225] Negative regulation by 'DCA:PDK2 [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-203946
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5362517] Signaling by Retinoic Acid [Pathway:R-BTA-204174] Regulation of pyruvate dehydrogenase (PDH) complex
(precedingEvent)	[Reaction:R-BTA-204169] PDP1,2 dephosphorylate p-lipo-PDH
(inferredTo)	[Reaction:R-HSA-203946] PDK isozymes phosphorylate PDHC subunit E1

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