Reactome | PDP1,2 dephosphorylate p-lipo-PDH

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PDP1,2 dephosphorylate p-lipo-PDH Show undefined attributes

catalystActivity	[CatalystActivity:10353596] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity of PDP [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10353598
displayName	PDP1,2 dephosphorylate p-lipo-PDH
eventOf	[Pathway:R-BTA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Bos taurus [Reaction:R-BTA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Bos taurus [Reaction:R-BTA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Bos taurus [Reaction:R-BTA-9861667] DLAT trimer transfers acetyl to CoA - Bos taurus
inferredFrom	[Reaction:R-HSA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [Complex:R-BTA-210342] p-lipo-PDH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PDP1,2 dephosphorylate p-lipo-PDH PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit Activation of PDC by dephosphorylation of phospho-E1 alpha component
output	[Complex:R-BTA-70070] PDH complex [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Bos taurus
regulatedBy	[Requirement:R-HSA-210326] Requirement by 'Mg2+ [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-204169
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-204174] Regulation of pyruvate dehydrogenase (PDH) complex
(precedingEvent)	[Reaction:R-BTA-9861616] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-BTA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT [Reaction:R-BTA-9861667] DLAT trimer transfers acetyl to CoA [Reaction:R-BTA-203946] PDK isozymes phosphorylate PDHC subunit E1
(inferredTo)	[Reaction:R-HSA-204169] PDP1,2 dephosphorylate p-lipo-PDH

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